| Développement : | Services : |
DéveloppementTechnologie |
| Berthet N., Leïchle T., Pourciel J-B., Saya D., Martin C., Bausells J., Lora-Tomayo E., Perez-Murano F., François J., Trevisiol E. and Nicu L. (2008). Interaction of biomolecules sequentially deposited at the same location with a microcantilever-based spotter. Biomed Microdevices, 10 (4), 479-487. |
| M. Geneviève, C. Vieu, R. Carles, A. Zwick, G. Brière, L. Salomé and E. Trévisiol (2007). Biofunctionalization of gold nanoparticles and their spectral properties. Microelectronic Engineering, 84, 1710-1713. |
| C. Thibault, C. Severac, E. Trévisiol and C. Vieu (2006). Microtransfer molding of hydrophobic dendrimer. Microelectronic Engineering, 83, 1513-1516. |
| Chaize B, Nguyen M, Ruysschaert T, le Berre V, Trevisiol E, Caminade AM, Majoral JP, Pratviel G, Meunier B, Winterhalter M, Fournier D. (2006). Microstructured liposome array Bioconjug Chem; 17(1):245-7. |
| Nicu, L., Guirardel, M., Chambosse, F., Rougerie, P., Hinh, S., Trevisiol, E., François, J., Majoral, JP, Caminade, A-M., Cattan, E. and Bergaud, C. (2005). First step towards a fully integrated microelectromechanically-based bioassay : detection of streptavidin-gold nanoparticles interaction with biotinylated DNA using micromachined piezoelectric membranes. Sensors & Actuators B, 110, 125 - 136. |
| Thibault C., Leberre V., Casimirius S., Trévisiol, E., François J. and Vieu C. (2005) Direct microcontact printing of oligonucleotides for biochips application. BMC. J. Nanobiotechnology 3:7 DOI:10.1186/1477-3155-3-7. |
| Belaubre P., Guirardel M., Le Berre V., Pourciel J.B. & Bergaud C. (2004). Cantilever-based microsystem for contact deposition of pivoliter biological samples. Sensors and Actuators: Physics A Issues 1-3, Vol.110, pp.130-135. |
| Vieu,C., Malaquin, L., Thibault, C., Saliba, A.E., Daran, E., Dilhan, M., Carcenac, F., Leberre, V., Trevisiol, E., François, J. (2004). Les Nanotechnologies au service des biopuces, l'exemple toulousain. Biofutur, 250, 41-46. |
|
L. Malaquin, C. Vieu, M. Geneviève, Y. Tauran, F. Carcenac, M. L. Pourciel, V. Leberre and E. Trévisiol (2004). Nanoelectrode-based devices for electrical biodetection in liquid solution. Microelectronic Engineering 73-74, 887-892, June 2004. |
|
Belaubre P., Guirardel M., Leberre V., Pourciel J.B. & Bergaud C. (2003). Cantilever-based microsystem for contact deposition of pivoliter biological samples. Sensors & Actuators A: Physical, Issues 1-3, Vol.110, pp.130-135, Février 2004. |
|
Veronique Le Berre, Emmanuelle Trevisiol, Adilia Dagkessamanskaia, Serguei Sokol, Anne-Marie Caminade, Jean Pierre Majoral, Bernard Meunier and Jean François (2003). Dendrimeric coating of glass slides for sensitive dna microarrays analysis. Nucleic acids research 31(16) 1-8 |
| Trévisiol, E., Le Berre, V., Leclaire, J., Pratviel, G., Caminade, A.M., Majoral, J.P., François, J. and Meunier, B.(2003). Dendrislides, Dendrichips: a simple chemical functionalization of glass slides as an effective mean for the preparation of biochips. New J.Chemistry 27,1713-1719 |
| Belaubre P., Guirardel M., Garcia G., Le Berre V., Dagkessamanskaia A., Trévisiol E., François J., Pourciel J.B., Bergaud C. Fabrication of biological microarrays using microcantilevers. Applied Physics Letters, Vol 82(18) pp. 3122-3124. May 5, 2003 |
| Jean François (2000). Les puces à ADN: Etat de l'art et nouveaux concepts. Bull. Soc.Fr. Microbiol., 15 (3) 2000. |
Brevets |
| C. Bergaud, B. Belier, A. Martinez, L. Nicu, E. Cocheteau. Biosensor matrix and method for making same. International patent WO 02/086479, October 10th, 2004. |
| C. Bergaud, P. Belaubre, M. Guirardel, B. Belier, J-B. Pourciel (2003). Device for the actively-controlled and localised deposition of at least one biological solution. International patent WO 03/097238, November 27th, 2003. |
| Trévisiol, E, Leclaire, J, Pratviel, G., Caminade, A-M, Majoral, J.P, François, J, Meunier, B. (2003). Solid supports functionalised by phosphorus dendrimers method for preparing same and uses therof. International patent WO 03/091304 A2, November 6th, 2003. |
| J.P. Roger, A.C. Boccara, C. Bergaud, M.C. Potier. Apparatus for parallel detection of the behaviour of mechanical micro-oscillators. International patent WO 02/37090, May 10th 2002. |
ServicesSanté |
| Marquez-Quinones, A., Paris, A., Roussel, B., Perez-Carreon, J., Le berre, V., François, J., Villa-Trevino, S. and Gueraud, F. (2007) Proteasome activity deregulation in LEC rat hepatitis : following the insights of transcriptomics analysis. Omics , 11, 367-384. |
| Anne Mazzucotelli, Nathalie Viguerie, Claire Tiraby, Jean-Sebastien Annicotte, Eva Klimcakova, Emmanuelle Lepin, Paul Delmar, Sebastien Dejean, Genevieve Tavernier, Corinne Lefort, Aline Mairal, Juan Hidalgo, Thierry Pineau, Lluis Fajas, Karine Clement and Dominique Langin (2007). The Transcriptional Coactivator PGC-1 Controls the Expression of Glycerol Kinase and Metabolic Genes Independently of PPARg Activation in Human White Adipocytes. Diabetes. Oct;56(10):2467-75. Epub 2007 Jul 23 |
| Viguerie N, Vidal H, Arner P, Holst C, Verdich C, Avizou S, Astrup A, Saris WH, Macdonald IA, Klimcakova E, Clement K, Martinez A, Hoffstedt J, Sorensen TI, Langin D. Nutrient-Gene Interactions in Human Obesity--Implications for Dietary Guideline (NUGENOB) project. Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets. Diabetologia. 2005 Jan; 48(1):123-31. |
| Mohamed Salah Allagui; Christian Vincent; Abdelfattah El Feki; Yolande Gaubin; Francoise Croute. Lithium toxicity and expression of stress related-genes or -proteins in A549 cells. BBA Molecular Cell Research, May 2007 |
| Perez-Carreon, J.I., Lopez-García, C., Fattel-Fazenda, S, Evelia Arce-Popoca, Aleman-Lazarini, L., Hernandez-Garcia, S., Le Berre, V., Sokol, S., Francois, J.M. and Villa-Trevino, S. (2006) Gene expression profiles related to the progression of preneoplastic nodules toward hepatocellular carcinoma in rats. Neoplasia (in press). |
| Martin PG, Guillou H, Lasserre F, Dejean S, Lan A, Pascussi JM, Sancristobal M, Legrand P, Besse P, Pineau T. (2007) Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study. Hepatology. 2007 Mar;45(3):767-77. PMID: 17326203 [PubMed - indexed for MEDLINE] |
| Roncalli J, Smih F, Desmoulin F, Dumonteil N, Harmancey R, Hennig S, Perez L, Pathak A, Galinier M, Massabuau P, Malet-Martino M, Senard JM, Rouet P. NMR and cDNA array analysis prior to heart failure reveals an increase of unsaturated lipids, a glutamine/glutamate ratio decrease and a specific transcriptome adaptation in obese rat heart. J Mol Cell Cardiol. 2007 Mar;42(3):526-39. Epub 2007 Jan 11. PMID: 17222424 [PubMed - in process] |
|
Pérez-Carreón, Julio Isael; López-García, Cristina; Fattel-Fazenda, Samia; Arce-Popoca, Evelia1; Alemán-Lazarini, Leticia; Hernández-García, Sergio1; Le Berre, Véronique; Sokol, Sergueï; Francois, Jean Marie; Villa-Treviño, Saúl (2006) Gene Expression Profile Related to the Progression of Preneoplastic Nodules toward Hepatocellular Carcinoma in Rats. Neoplasia, Volume 8, Number 5, May 2006, pp. 373-383(11) DOI: 10.1593/neo.05841 |
| H. Laurell, M. Bouisson, P. Berthélemy, P. Rochaix, S. Déjean, P. Besse, C. Susini, L. Pradayrol, N. Vaysse, L. Buscail (2006). Identification of biomarkers of human pancreatic adenocarcinomas by expression profiling and validation by gene expression analysis in Endoscopic Ultrasound-guided Fine Needle Aspiration samples. World Journal of Gastroenterology, to appear (2006) |
| Martin, Pascal G. P. ; Lasserre, Frederic ; Calleja, Cecile ; Van es, Armelle ; Roulet, Alain ; Concordet, Didier ; Cantiello, Michela ; Barnouin, Romain ; Gauthier, Beatrice ; Pineau, Thierry. Transcriptional Modulations by RXR Agonists Are Only Partially Subordinated to PPARa Signaling and Attest Additional, Organ-Specific, Molecular Cross-Talks. Gene Expression 2005. 12(3):177-192 |
| Croute F, Beau B, Murat JC, Vincent C, Komatsu H, Obata F, Soleilhavoup JP. Expression of stress-related genes in a cadmium-resistant A549 human cell-line. J. Toxicol Environ Health, 2005, 68:703-718 |
| Dagkessamanskaia, A., Moscoso, M., Hénard, V., Guiral, S., Overweg, K., Reuter, M., Martin, B., Wells, J. and Claverys, J.P. (2004). Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells. Mol. Microbiol. 51, 1071-1086. |
|
Philip-Couderc P., Smih F., Hall JE., Pathak A., Roncalli J., Harmancey R., Massabuau P., Galinier M., Verwaerde P., Senard J-M and Rouet P. (2004). Kinetic analysis of cardiac transcriptome regulation during chronic high fat diet in dogs. Physiological Genomics. 2004 ; Sep 16;19(1):32-40. |
| Philip-Couderc P., Pathak A., Smih F., Dambrin C., Harmancey R., Buys S., Galinier M., Massabuau P., Roncalli J., Senard J-M., and Rouet P. (2004). Uncomplicated human obesity is associated with a specific cardiac transcriptome: involment of the Wnt pathway. FASEB J. 2004 Oct;18(13):1539-40. |
|
Terence N. LEDGER, Philippe PINTON, Dorothée BOURGES, Patrick ROUMI, Henri SALMON, and Isabelle P. OSWALD (2004). Development of a macroarray to specifically analyse immunological gene expression in swine. Clinical And Diagnostic Laboratory Immunology, 2004 Jul;11(4):691-8. |
|
Philip-Couderc P, Smih F, Pelat M, Vidal C, Verwaerde P, Pathak A, Buys S, Galinier M, Senard JM, Rouet P. (2003). Cardiac transcriptome analysis in obesity-related hypertension. Hypertension 2003 Mar; 41(3):414-21. |
|
Charriere G, Cousin B, Arnaud E, Andre M, Bacou F, Penicaud L, Casteilla L. Preadipocyte conversion to macrophage. Evidence of plasticity. J. Biol. Chem., Vol. 278, Issue 11, 9850-9855, March 14, 2003. |
| Gaubin Y, Manceau C, Skandrani D, Croute F, Murat J.C, Soleilhavoup JP. Changes in level of genes expression after exposure of cultured human cells to endosulfan as investigated by cDNA microarrays method. Fresenius Environ Bull 2002, 8, 466-468. |
| Veronique Le Berre-Anton et Jean François. Avenir des puces à ADN dans les maladies infectieuses. Antibiotiques 2002; 4:11-17 |
Microbiologie |
| Leberre, V., Baranowski, E., Delplanche, M. Trouilh, L. and François, J. (2007). Detection of minority variants within bovine respiratory syncytial RNA virus population using oligonucleotide-based microarrays. J. Virol Method doi:10.1016/j.jviromet.2007.10.026. |
| Cholet O, Henaut A, Casaregola S, Bonnarme P. (2007). Gene expression and biochemical analysis of cheese-ripening yeasts: focus on catabolism of L-methionine, lactate, and lactose. Appl Environ Microbiol. 2007 Apr;73(8):2561-70. Epub 2007 Feb 16. |
| Cholet O, Henaut A, Bonnarme P. (2007). Transcriptional analysis of L-methionine catabolism in Brevibacterium linens ATCC9175. Appl Microbiol Biotechnol. 2007 Apr;74(6):1320-32. Epub 2007 Jan 16. |
| Guidot A., Prior P., Schoenfeld J, Carrère S., Genin S., Boucher C. (2006) Genomic structure and phylogenyof the plant pathogen Ralstonia solanacearum as inferred from gene distribution analysis. J. Bacteriol (in press) |
| Valls M, Genin S, Boucher C (2006). Integrated regulation of the type III secretion system and other virulence determinants in Ralstonia solanacearum PLos Pathogens PLoS Pathog. 2006 Aug 25;2(8). |
| Novo, M., Beltran, G., Rozes, N., Guillamon, J-M., Sokol, S., Leberre, V., François, J., and Mas, A. (2007). Early transcriptional response of wine yeast after rehydration : Osmotic shock and metabolic activation. FEMS Yeast Res. 7, 304 - 316. |
| Kuranda, K., Leberre, V., Sokol, S., Palamarczyk, G. and François, J. (2006). Investigating the caffeine effects in the yeast Saccharomyces cerevisiae brings new insights into the connection between TOR, PKC and Ras/cAMP signalling pathways. Mol. Microbiol. 61 (5), 1147 - 1166. |
| Scherens B, Feller A, Vierendeels F, Messenguy F, Dubois E. (2006). Identification of direct and indirect targets of the Gln3 and Gat1 activators by transcriptional profiling in response to nitrogen availability in the short and long term. FEMS Yeast Res. 2006 Aug;6(5):777-91. |
| Cyril Bontemps, Geoffroy Golfier, Carine Gris-Liebe, Sébastien Carrere, Luc Talini and Catherine Boivin-Masson (2005). Microarray-based detection and typing of the rhizobium nodulation gene nodC: the potential of DNA arrays to diagnose biological functions of interest. Appl. Environ. Microbiol. 71:8042-8048. |
| Occhialini A, Cunnac S, Reymond N, Genin S, Boucher C. (2005). Genome-wide analysis of gene expression in Ralstonia solanacearum reveals that the hrpB gene acts as a regulatory switch controlling multiple virulence pathways. Mol Plant Microbe Interact. 2005; 18:938-49. |
|
Gemma Beltran, Maite Novo, Véronique Leberre, Serguei Sokol, Delphine Labourdette, José-Manuel Guillamon, Alberto Mas, Jean Francois, Nicolas Rozes Integration of transcriptomic and metabolic analyses for understanding the global responses of low-temperature winemaking fermentations Fems Yeast Research, Online publication date: 24-May-2006, doi:10.1111/j.1567-1364.2006.00106.x . |
| Redon E., Loubiere P., *Cocaign-Bousquet M. (2005). Transcriptome analysis of the progressive adaptation of Lactococcus lactis to carbon starvation. Journal of bacteriology. 187:3589-3592. |
| Raynaud S., Perrin R., Cocaign-Bousuqet M., Loubiere P. (2005). Metabolic and transcriptomic adaptation of Lactococcus lactis subsp. lactis/biovar/diacetylactis strain in response to auto-acidification and temperature downshift in skim milk. Applied and Environmental Microbiology, 71:8016-8023. |
|
Lagorce A, Hauser NC, Labourdette D, Rodriguez C, Martin-Yken H, Arroyo J, Hoheisel JD, Francois J. (2003). Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae. J Biol Chem 2003 Mar 18 PMID: 12644457. |
|
Even S., Lindley N. D., Cocaign-Bousquet M. Transcriptional, translational and metabolic regulation of glycolysis in Lactococcus lactis subsp. cremoris MG 1363 grown in continuous acidic cultures. Microbiology, 2003 Jul;149(Pt 7):1935-44. |
|
Even S., Lindley N. D., Loubiere P., Cocaign-Bousquet M. (2002). Dynamic response of catabolic pathways to auto-acidification in Lactococcus lactis: transcript profiling in relation to metabolic and energetic constraints. Molecular Microbiology, 2002, 45:1143-1152. |
| Fontaine L., Even S., Soucaille P., LINDLEY N. D., Cocaign-Bousquet M. (2001). Transcript quantification based on chemical labelling of RNA associated to fluorescent detection. Analytical Biochemistry,(2001) 298:246-252. |
| Even S., Lindley N. D., Cocaign-Bousquet M. (2001). Molecular physiology of sugar catabolism in Lactococcus lactis IL 1403. Journal of Bacteriology 183:3817-3824. |
|
Hélène Bergès, Emmanuelle Lauber, Carine Liebe, Jacques Batut, Daniel Kahn, Frans J. de Bruijn, and Frédéric Ampe (2003). Development of Sinorhizobium meliloti Pilot Macroarrays for Transcriptome Analysis. Applied and Environmental Microbiology, Feb. 2003; p.1214-1219. |
Plantes |
| Godiard L., Niebel A., Micheli F., Gouzy J., Ott T., and Gamas P. (2007). Identification of a new set of potential regulators of the Medicago truncatula-Sinorhizobium meliloti symbiosis using a large scale Suppression Subtractive Hybridization approach. MPMI, 2007. 20 (3), 321-332. |
| Merchan F., de Lorenzo L., Gonzalez-Rizzo S., Niebel, A., Manyani H., Frugier F., Sousa, C., Crespi, M. (2007). Identification of regulatory pathways involved in the reacquisition of root growth after salt stress in Medicago truncatula. Plant Journal, 2007 May 3; Epub ahead of print. |